Chakravarty K, Tucker W, Rosen M, Vickers M D
Br Med J. 1979 Oct 13;2(6195):895-7. doi: 10.1136/bmj.2.6195.895.
In a double-blind study of on-demand intravenous analgesia buprenorphine was found to be about 600 times as potent as pethidine. The incidence of side effects was similar with both drugs. The quality of analgesia, subjectively assessed, was good with both drugs using this method of administration. Provided that its low potential for abuse is substantiated, buprenorphine appears to be a powerful analgesic that may successfully be given intravenously on demand.
在一项按需静脉镇痛的双盲研究中，发现丁丙诺啡的效力约为哌替啶的600倍。两种药物的副作用发生率相似。通过这种给药方法主观评估，两种药物的镇痛质量都很好。如果其低滥用可能性得到证实，丁丙诺啡似乎是一种强效镇痛药，可按需成功静脉给药。
