Samoĭlova Z T, Shul'tseva G P, Lebkova N P, Kolesova O E, Khaliutina L V
Kardiologiia. 1978 Feb;18(2):106-10.
Functional structural changes in the myocardium in different developmental phases of nephrotoxic glomerulonephritis were studied in rats. Electrocardiography, electron microscopy, and biochemical study of respiration, linked with oxidative phosphorylation, by polarography in the fraction of mitochondria isolated by differential centrifugation were employed. In experimental glomerulonephritis the ECG shifts were attended with diminished oxidative phosphorylation in the myocardial mitochondria, destructive changes in the cardiomyocytes (disorganization of mitochondria, myofibrils, endoplasmic reticulum), loosening and swelling of the basilar membranes, and changes and swelling in the capillaries and interstitium. The functional structural changes in the heart are reversible in character but persist for a longer period of time than the clinical manifestations of glomerulonephritis.
在大鼠中研究了肾毒性肾小球肾炎不同发育阶段心肌的功能结构变化。采用了心电图、电子显微镜检查，以及通过差速离心分离的线粒体部分中的呼吸与氧化磷酸化相关的生化研究（通过极谱法）。在实验性肾小球肾炎中，心电图改变伴随着心肌线粒体氧化磷酸化减少、心肌细胞的破坏性变化（线粒体、肌原纤维、内质网紊乱）、基底膜疏松和肿胀，以及毛细血管和间质的变化和肿胀。心脏的功能结构变化具有可逆性，但比肾小球肾炎的临床表现持续时间更长。
