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[肾毒性肾小球肾炎大鼠心肌的亚细胞变化]

[Subcellular changes in rat myocardium in nephrotoxic glomerulonephritis].

作者信息

Lebkova N P, Samoilova Z T

出版信息

Biull Eksp Biol Med. 1976 Sep;82(9):1123-6.

PMID:990475
Abstract

Disorganization of the mitochondria, myofibrillae, sarcolemma, intra- and intercellular edema, swelling and pyknosis of the endothelium, capillary obstruction by the blood elements, thickening of the basal membranes were revealed in the myocardium of rats with Mazugi nephritis. The maximum changes were observed on the 10--20th day after the onset of the reproduction of glomerulonephritis; the intracellular regenerative processes became intensified from the 20th day. There was a correlation in the dynamics of the subcellular histological and clinical manifestations of glomerulonephritis.

摘要

在患有真木肾炎的大鼠心肌中,发现线粒体、肌原纤维、肌膜出现紊乱,细胞内和细胞间水肿,内皮细胞肿胀和固缩,血液成分阻塞毛细血管,基底膜增厚。在肾小球肾炎复制开始后的第10 - 20天观察到最大变化;从第20天起细胞内再生过程增强。肾小球肾炎的亚细胞组织学和临床表现的动态之间存在相关性。

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