Karimov M K, Belkin V Sh, Ataev F M, Bobozhonov M N
Morfologiia. 1994 Apr-Jun;106(4-6):117-24.
The investigation was performed in 64 male albino rats, 18 of which stayed in comfortable conditions (control), while 48 were kept everyday for 4 hrs in open sun ground at temperature 30-40 degrees C during 3 months. Vascular-structural reorganizations in the myocardium of experimental animals developed during 1-15 days. Capillary-tissue disturbances increase with characteristic morphological manifestations of the blood circulation disorders prevailing in the left and right ventricles, sharp increase of vessel and capillary wall permeability, loosening of the organ stroma, dystrophic and degenerative processes in cardiomyocytes, presence of diapedese haemorrhages and decrease of glycogen content. From day 16 up to day 30 capillary-tissue disorders and manifestations of the structural-anatomic reorganizations subside although intramural blood circulation changes persist as well as single degenerative changes in cardiomyocytes and oedematous changes of the connective tissue framework. At later stages, up to day 90 the formed structural anatomical reorganizations stabolize, the signs of blood circulation disturbances disappear to significant extent, but complete normalization of microscopic myocardial structure does not occur.
该研究在64只雄性白化大鼠身上进行，其中18只处于舒适环境（对照组），而48只在3个月内每天于30 - 40摄氏度的露天场地中放置4小时。实验动物心肌的血管结构重组在1 - 15天内形成。毛细血管组织紊乱加剧，其特征为左右心室血液循环障碍的典型形态学表现，血管和毛细血管壁通透性急剧增加，器官基质疏松，心肌细胞出现营养不良和退行性变，存在血细胞渗出性出血以及糖原含量降低。从第16天到第30天，毛细血管组织紊乱以及结构 - 解剖重组的表现消退，尽管壁内血液循环变化持续存在，心肌细胞仍有单个退行性变化以及结缔组织框架的水肿变化。在后期，直至第90天，已形成的结构 - 解剖重组趋于稳定，血液循环障碍的迹象在很大程度上消失，但心肌微观结构并未完全恢复正常。
