Moreno C, Hale C
Eur J Immunol. 1976 Nov;6(11):773-7. doi: 10.1002/eji.1830061104.
Fractions of dextrian (DE) B512, DE B1355 and levan (LE) have been shown to induce a specific blockade of antibody-forming cells (AFC) when injected into previously immunized mice. Whereas specific blockade with DE B512 (450 000 daltons) was easily induced by as little as 10 mug, blockade to LE and DE B1355 was more resistant and required 1 and 10 mg, respectively. AFC blockade and tolerance are dissociable phenomena, as the former effect could be achieved with nontolerogenic low mol. wt DE B512 (10 000 daltons). Conversely, perennial rye grass fructosan (7600 daltons), which is tolerogenic for LE, did not induce a blockade. Furthermore, blockade of anti-DE response specific for alpha (1 leads to 3)-linked glucosyl determinants was achieved in BALB/c mice, whereas attempts to induce stable tolerance have been unsuccessful.
已证明，将右旋糖酐（DE）B512、DE B1355和果聚糖（LE）的组分注射到预先免疫的小鼠体内时，可诱导抗体形成细胞（AFC）的特异性阻断。用DE B512（450000道尔顿）进行特异性阻断时，低至10微克即可轻易诱导，而对LE和DE B1355的阻断则更具抗性，分别需要1毫克和10毫克。AFC阻断和耐受性是可分离的现象，因为前一种效应可以用非耐受性的低分子量DE B512（10000道尔顿）实现。相反，对LE具有耐受性的多年生黑麦草果聚糖（7600道尔顿）不会诱导阻断。此外，在BALB/c小鼠中实现了对α（1→3）连接的葡萄糖基决定簇特异性的抗DE反应的阻断，而诱导稳定耐受性的尝试未成功。
