Chaouat G, Howard J G
Immunology. 1976 Feb;30(2):221-7.
The intensity of reticuloendothelial blockade by carrageenan, silica and ethyl stearate was measured and its effect studied on the susceptibility to tolerance induction by polysaccharide antigens in mice. The most intense RE depression reduced the tolerance threshold dose of levan only by 3-fold and that of dextran B512 not at all. The genetic resistance of BALB/c mice to tolerization with the alpha1-3 glucose epitope of dextran B1355 was not overcome by carrageenan blockade which did however, render them normally susceptible to tolerance induction by human gamma-globulin. PFC responses to immunization by the polysaccharides were diminished by blockade, relative to its intensity and to the antigen itself. These and other data suggest that severe RE blockade (a) can promote tolerance by suppressing the active role(s) of the macrophages in immune induction rather than by sustaining circulating antigen, and (b) depresses responses to thymus-independent antigens, probably by an immunosuppressive influence mediated by damaged macrophages.
测定了角叉菜胶、二氧化硅和硬脂酸乙酯对网状内皮系统的阻断强度，并研究了其对小鼠多糖抗原诱导耐受性易感性的影响。最强的网状内皮系统抑制作用仅使左聚糖的耐受阈值剂量降低了3倍，而对葡聚糖B512则完全没有影响。角叉菜胶阻断并未克服BALB/c小鼠对葡聚糖B1355的α1-3葡萄糖表位耐受的遗传抗性，但却使其对人γ球蛋白诱导的耐受性正常敏感。相对于阻断强度和抗原本身，阻断作用使对多糖免疫的PFC反应减弱。这些及其他数据表明，严重的网状内皮系统阻断（a）可通过抑制巨噬细胞在免疫诱导中的活性作用而非维持循环抗原促进耐受性，（b）可能通过受损巨噬细胞介导的免疫抑制作用抑制对胸腺非依赖性抗原的反应。
