Spencer G S, Hill D J, Garssen G J, Macdonald A A, Colenbrander B
J Endocrinol. 1983 Jan;96(1):107-14. doi: 10.1677/joe.0.0960107.
Chronic hyperinsulinaemia in the presence of euglycaemia was obtained in pig fetuses between 90 and 104 days gestational age (term is 114 days) by the implantation of insulin-filled osmotic minipumps. At 104 days these fetuses were compared with both saline-implanted controls and with unoperated fetuses from the same sows. Mean plasma GH levels were the same in all three treatment groups and were much greater than in the maternal peripheral venous circulation. Levels of GH in amniotic fluid were low, and even lower levels were measured in lung fluid. Glucose and protein levels were also lower in amniotic fluid than in plasma and lower still in lung fluid. In contrast, somatomedin activity was higher in amniotic and lung fluids than in fetal plasma and, when expressed relative to protein content, was highest in lung fluid. Insulin-treated fetuses had significantly (P less than 0.05) higher levels of somatomedin activity than control fetuses, but despite this were neither longer nor heavier than control fetuses. From these data it is concluded that neither insulin nor somatomedin directly affect fetal growth.
通过植入充满胰岛素的渗透微型泵，在妊娠90至104天（足月为114天）的猪胎儿中实现了在血糖正常情况下的慢性高胰岛素血症。在104天时，将这些胎儿与植入生理盐水的对照组以及来自同一母猪的未手术胎儿进行比较。所有三个治疗组的平均血浆生长激素水平相同，且远高于母体外周静脉循环中的水平。羊水中的生长激素水平较低，肺液中的水平更低。羊水和血浆中的葡萄糖和蛋白质水平也低于血浆，肺液中的水平更低。相比之下，羊水中和肺液中的生长调节素活性高于胎儿血浆，相对于蛋白质含量而言，肺液中的活性最高。胰岛素治疗的胎儿的生长调节素活性水平显著（P小于0.05）高于对照胎儿，但尽管如此，其长度和体重均不比对照胎儿长或重。从这些数据可以得出结论，胰岛素和生长调节素均不直接影响胎儿生长。
