Belizan J M, Villar J, Pineda O, Gonzalez A E, Sainz E, Garrera G, Sibrian R
JAMA. 1983 Mar 4;249(9):1161-5.
Epidemiologic and animal studies have suggested an inverse relationship between calcium intake and BP. Furthermore, calcium intake seems to be inversely correlated with the incidence of eclampsia in pregnancy. In a randomized clinical trial, young adults were allocated to a calcium-supplemented group receiving 1 g/day of elemental calcium (15 men and 15 women) or a placebo group (14 women and 13 men) for a period of 22 weeks. The calcium-supplemented group showed a significant decrease in diastolic BP; this effect was stabilized after nine weeks in women and six weeks in men. The reduction in diastolic BP was 5.6% and 9% from the initial values for women and men, respectively. This study supports epidemiologic and animal evidence of the effect of calcium intake on BP and suggests the need for more research exploring the mechanisms involved in the observed effect.
流行病学和动物研究表明钙摄入量与血压之间存在负相关关系。此外，钙摄入量似乎与妊娠期子痫的发生率呈负相关。在一项随机临床试验中，将年轻人分为补充钙组（每天摄入1克元素钙，15名男性和15名女性）或安慰剂组（14名女性和13名男性），为期22周。补充钙组的舒张压显著降低；女性在9周后、男性在6周后这种效果趋于稳定。女性和男性的舒张压分别较初始值降低了5.6%和9%。这项研究支持了钙摄入量对血压影响的流行病学和动物证据，并表明需要更多研究来探索所观察到的效果背后的机制。
