Department of Cardiology, Beijing Chao-Yang Hospital, No. 8 Gongti South Road, Chaoyang District, Beijing, 100043, China.
Children's Hospital, Capital Medical University, Beijing, China.
Lipids Health Dis. 2020 Apr 25;19(1):79. doi: 10.1186/s12944-020-01259-x.
Fermented milk has over the last decade been intensively studied because of the putative antihypertensive effect. The aim of our study is to investigate the role of probiotics support therapy in blood pressure and, as a kind of convenient and economic drugs for prevention and auxiliary treatment of hypertension.
We performed a systemic review and meta-analysis to examine the effect of probiotics consumption on blood pressure. Databases including MEDLINE, EMBASE, Clinical trials, CNKI and the Cochrane library were searched. Also, the grey literature and references were searched.
Twenty-three randomized controlled trials (RCTs) involving 2037 participants met the inclusion criteria and were included. Probiotic consumption significantly changed systolic blood pressure (SBP) by - 3.05 mmHg (95%CI: - 4.67, - 1.44; P < 0.001) and diastolic blood pressure (DBP) by - 1.51 mmHg (95%CI: - 2.38, - 0.65; P = 0.001). Subgroup analysis indicated that the benefit effect of probiotics supplementation in SBP was only observed in hypertension [weight mean difference (WMD) = - 3.31 mmHg, 95%CI: - 5.71, - 0.92; P = 0.007] or type 2 diabetes (WMD = -4.85 mmHg, 95%CI: - 9.28, - 0.42; P = 0.032) patients, and the decreased DBP level by probiotics supplementation was only observed in hypertension patients (WMD = -2.02 mmHg, 95%CI: - 3.68, - 0.36; P = 0.017).This effect could only last for a short-term time of 8 or 10 weeks, but not for a long-term time.
This meta-analysis found a moderate and statistically significant reduction for either SBP or DBP with probiotics supplement compared with controls. Thus, probiotics is a potential for the dietary treatment of hypertension.
由于发酵乳具有潜在的降压作用，在过去十年中，它已被深入研究。我们的研究旨在探讨益生菌支持治疗在血压方面的作用，以及作为一种方便且经济的高血压预防和辅助治疗药物。
我们进行了系统评价和荟萃分析，以检查益生菌摄入对血压的影响。检索了 MEDLINE、EMBASE、临床试验、中国知网和 Cochrane 图书馆等数据库，并检索了灰色文献和参考文献。
共有 23 项随机对照试验（RCT）纳入了 2037 名参与者，符合纳入标准。益生菌摄入可显著降低收缩压（SBP）-3.05mmHg（95%CI：-4.67，-1.44；P<0.001）和舒张压（DBP）-1.51mmHg（95%CI：-2.38，-0.65；P=0.001）。亚组分析表明，益生菌补充对 SBP 的有益作用仅在高血压[加权均数差（WMD）=-3.31mmHg，95%CI：-5.71，-0.92；P=0.007]或 2 型糖尿病（WMD=-4.85mmHg，95%CI：-9.28，-0.42；P=0.032）患者中观察到，而益生菌补充对 DBP 的降低作用仅在高血压患者中观察到（WMD=-2.02mmHg，95%CI：-3.68，-0.36；P=0.017）。这种作用只能持续 8 或 10 周的短期时间，而不能持续很长时间。
与对照组相比，本荟萃分析发现益生菌补充剂可使 SBP 或 DBP 适度且具有统计学意义的降低。因此，益生菌可能是高血压饮食治疗的一种潜在方法。
