血液透析期间使用血栓素合成酶抑制剂达唑氧苯。
Use of a thromboxane synthetase inhibitor, dazoxiben, during haemodialysis.
作者信息
Dodd N J, Gordge M P, Weston M J
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 1(Suppl 1):67S-70S. doi: 10.1111/j.1365-2125.1983.tb02110.x.
Abstract
1 We have assessed the thromboxane synthetase inhibitor, dazoxiben (UK 37248), during dialysis in a double-blind, placebo-controlled crossover study. 2 Thromboxane generation was markedly inhibited, and there was an increase in serum 6-keto prostaglandin F1 alpha levels during active treatment studies. 3 We were unable to demonstrate any reduction of platelet activation, or dialyser fibrin deposition, nor were heparin requirements altered by the drug. 4 Dazoxiben had no adverse effects.
摘要
我们在一项双盲、安慰剂对照的交叉研究中评估了血栓素合成酶抑制剂达唑氧苯（UK 37248）在透析过程中的作用。
在积极治疗研究期间，血栓素的生成受到显著抑制，血清6-酮前列腺素F1α水平有所升高。
我们未能证明血小板活化或透析器纤维蛋白沉积有任何减少，该药物也未改变肝素的用量。
达唑氧苯没有不良反应。
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本文引用的文献
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2
Platelet protection and heparin sparing with prostacyclin during regular dialysis therapy.在常规透析治疗期间使用前列环素进行血小板保护和肝素节约。
Lancet. 1980 Aug 2;2(8188):219-22. doi: 10.1016/s0140-6736(80)90116-6.
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Haemostatic changes during dialysis associated with thrombus formation on dialysis membranes.透析过程中与透析膜上血栓形成相关的止血变化。
Br Med J. 1972 Nov 25;4(5838):454-8. doi: 10.1136/bmj.4.5838.454.
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Prostaglandin D2 inhibits the aggregation of human platelets.前列腺素D2抑制人血小板的聚集。
Thromb Res. 1974 Sep;5(3):291-9. doi: 10.1016/0049-3848(74)90168-6.
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Reduction of thrombus formation on dialyser membranes by aspirin and RA 233.阿司匹林和RA 233对透析器膜上血栓形成的抑制作用
Lancet. 1972 Dec 16;2(7790):1287-90. doi: 10.1016/s0140-6736(72)92656-6.
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Reduction of dialyzer fibrin deposition with sulphinpyrazone.用磺吡酮减少透析器纤维蛋白沉积。
Clin Nephrol. 1979 Sep;12(3):122-6.
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Physiological and pharmacological roles of prostaglandins.前列腺素的生理和药理作用。
Annu Rev Pharmacol. 1975;15:285-306. doi: 10.1146/annurev.pa.15.040175.001441.
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