Siegers C P, Younes M
Pharmacol Res Commun. 1983 Jan;15(1):1-13. doi: 10.1016/s0031-6989(83)80075-7.
Glutathione displays important functions in living cells of many species, human included. Apart from its direct antioxidative activity, which supports the maintenance of the reduced state of proteinthiols, and its possible role in amino acid transport across membranes, it appears to exert several detoxification functions. These include the conjugation of electrophilic compounds and the reduction of H2O2 and lipid hydroperoxides. Disorders in GSH synthesis and metabolism are known and produce hemolysis in the first place. Little data exist concerning GSH and the GSH-dependent enzymes involved in its various functions in normal and diseased human tissues. The aim of this review is to stimulate research in this area.
谷胱甘肽在包括人类在内的许多物种的活细胞中发挥着重要作用。除了其直接的抗氧化活性（支持维持蛋白质硫醇的还原状态）以及在氨基酸跨膜转运中的可能作用外，它似乎还发挥着多种解毒功能。这些功能包括亲电子化合物的结合以及过氧化氢和脂质氢过氧化物的还原。已知谷胱甘肽合成和代谢紊乱首先会导致溶血。关于正常和患病人体组织中谷胱甘肽及其参与各种功能的依赖谷胱甘肽的酶的数据很少。本综述的目的是激发该领域的研究。
