Hoppenkamps R, Thies E, Younes M, Siegers C P
Klin Wochenschr. 1984 Feb 15;62(4):183-6. doi: 10.1007/BF01731642.
The gamma-glutamyl-transferase activity, the total glutathione content, the GSH-peroxidase activity, and the GSH S-transferase activity using an aryl substrate were estimated in the S9 fraction of gastric biopsy specimens taken from patients with normal stomach morphology (n = 24), acute gastritis (n = 15), chronic-atrophic gastritis (n = 10), gastric ulcer (n = 9), and carcinoma of the stomach (n = 12). The total glutathione content of normal gastric mucosal specimens was significantly higher than that of human liver biopsy specimens, whereas the GSH-peroxidase and the GSH S-aryltransferase activities were much lower than those found in the liver. Specimens of gastric ulcer had significantly lower enzyme activities of GSH-peroxidase and GSH-aryltransferase, whereas gastric cancer tissue had significantly lower concentrations of total glutathione. The intraindividual comparison of tumorous and non-tumorous tissue showed a consistent decrease of total glutathione as well as of GSH-aryltransferase activity in carcinomatous tissue.
对取自胃形态正常患者（n = 24）、急性胃炎患者（n = 15）、慢性萎缩性胃炎患者（n = 10）、胃溃疡患者（n = 9）和胃癌患者（n = 12）的胃活检标本的S9组分，测定了γ-谷氨酰转移酶活性、总谷胱甘肽含量、谷胱甘肽过氧化物酶活性以及使用芳基底物的谷胱甘肽S-转移酶活性。正常胃黏膜标本的总谷胱甘肽含量显著高于人肝活检标本，而谷胱甘肽过氧化物酶和谷胱甘肽S-芳基转移酶活性则远低于肝脏中的活性。胃溃疡标本的谷胱甘肽过氧化物酶和谷胱甘肽芳基转移酶的酶活性显著较低，而胃癌组织的总谷胱甘肽浓度显著较低。肿瘤组织与非肿瘤组织的个体内比较显示，癌组织中的总谷胱甘肽以及谷胱甘肽芳基转移酶活性持续下降。
