Clarke-Pearson D L, Coleman R E, Synan I S, Hinshaw W, Creasman W T
Am J Obstet Gynecol. 1983 Mar 1;145(5):606-13. doi: 10.1016/0002-9378(83)91205-x.
One hundred eighty-five patients undergoing operation for gynecologic malignancy participated in a randomized controlled trial of low-dose heparin prophylaxis. Prospective surveillance for deep venous thrombosis was performed with daily fibrinogen 125I counting in the legs and impedance plethysmography. Twelve of 97 (12.4%) patients in the control group and 13 of 88 (14.8%) patients in the low-dose heparin group developed a venous thromboembolic complication. There was no statistical difference in the incidence of proximal deep vein thrombosis, calf vein thrombosis, or pulmonary emboli between the control and low-dose heparin groups. Low-dose heparin does not afford any prophylactic benefit to patients undergoing major pelvic operative procedures for gynecologic malignancy.
185例接受妇科恶性肿瘤手术的患者参与了一项低剂量肝素预防的随机对照试验。通过每日对腿部纤维蛋白原125I计数和阻抗体积描记法对深静脉血栓形成进行前瞻性监测。对照组97例患者中有12例（12.4%），低剂量肝素组88例患者中有13例（14.8%）发生了静脉血栓栓塞并发症。对照组和低剂量肝素组之间近端深静脉血栓形成、小腿静脉血栓形成或肺栓塞的发生率没有统计学差异。低剂量肝素对接受妇科恶性肿瘤大型盆腔手术的患者没有任何预防益处。
