Clarke-Pearson D L, Creasman W T, Coleman R E, Synan I S, Hinshaw W M
Gynecol Oncol. 1984 Jun;18(2):226-32. doi: 10.1016/0090-8258(84)90030-1.
Postoperative venous thromboembolic complications are a major problem for the gynecologic oncologist. External pneumatic calf compression (EPC), when applied intraoperatively and left on the patient's legs for 5 days postoperatively, has been previously demonstrated to significantly reduce the incidence of venous thromboembolic complications in patients undergoing surgery for pelvic malignancies. The purpose of this study is to evaluate whether a short perioperative course of EPC is also effective in preventing venous thromboembolic complications. One hundred ninety-four patients participated in a randomized controlled trial of perioperative external pneumatic calf compression. 125I-labeled fibrinogen scanning and impedance plethysmography were used as prospective surveillance methods in both groups. Venous thromboembolic complications were diagnosed in 12.4% of control group patients and in 18.6% of EPC group patients. External pneumatic calf compression when used only in the perioperative period appears to be of no benefit in reducing the incidence of postoperative venous thromboembolic complications.
术后静脉血栓栓塞并发症是妇科肿瘤医生面临的一个主要问题。外部气动小腿压迫（EPC），若在术中应用并在术后5天留置在患者腿部，此前已证明可显著降低盆腔恶性肿瘤手术患者静脉血栓栓塞并发症的发生率。本研究的目的是评估围手术期短期应用EPC在预防静脉血栓栓塞并发症方面是否也有效。194例患者参与了围手术期外部气动小腿压迫的随机对照试验。两组均采用125I标记纤维蛋白原扫描和阻抗体积描记法作为前瞻性监测方法。对照组患者中有12.4%被诊断为静脉血栓栓塞并发症，EPC组患者中有18.6%被诊断为静脉血栓栓塞并发症。仅在围手术期使用外部气动小腿压迫似乎对降低术后静脉血栓栓塞并发症的发生率没有益处。
