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Radioiodination of botulinum neurotoxin type A with retention of biological activity and its binding to brain synaptosomes.

作者信息

Williams R S, Tse C K, Dolly J O, Hambleton P, Melling J

出版信息

Eur J Biochem. 1983 Mar 15;131(2):437-45. doi: 10.1111/j.1432-1033.1983.tb07282.x.

DOI:10.1111/j.1432-1033.1983.tb07282.x
PMID:6339240
Abstract
摘要

相似文献

1
Radioiodination of botulinum neurotoxin type A with retention of biological activity and its binding to brain synaptosomes.
Eur J Biochem. 1983 Mar 15;131(2):437-45. doi: 10.1111/j.1432-1033.1983.tb07282.x.
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Properties of a protease-sensitive acceptor component in mouse brain synaptosomes for Clostridium botulinum type B neurotoxin.
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Localization of sites for 125I-labelled botulinum neurotoxin at murine neuromuscular junction and its binding to rat brain synaptosomes.125I标记的肉毒杆菌神经毒素在小鼠神经肌肉接头处的定位及其与大鼠脑突触体的结合
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Botulinum neurotoxin type B. Its purification, radioiodination and interaction with rat-brain synaptosomal membranes.B型肉毒杆菌神经毒素。其纯化、放射性碘化及与大鼠脑突触体膜的相互作用。
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Binding ability of Clostridium botulinum neurotoxin to the synaptosome upon treatment of various kinds of the enzymes.
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Binding of Clostridium botulinum type C neurotoxin to rat brain synaptosomes.
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Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity.胰蛋白酶对A型肉毒梭菌神经毒素的灭活作用及两个胰蛋白酶裂解片段的纯化。重链亚基羧基末端附近的蛋白水解作用会破坏毒素结合活性。
Eur J Biochem. 1985 Aug 15;151(1):75-82. doi: 10.1111/j.1432-1033.1985.tb09070.x.

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Neuronal entry and high neurotoxicity of botulinum neurotoxin A require its N-terminal binding sub-domain.
神经毒素 A 进入神经元并具有高神经毒性需要其 N 端结合亚结构域。
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The ultimate radiochemical nightmare: upon radio-iodination of Botulinum neurotoxin A, the introduced iodine atom itself seems to be fatal for the bioactivity of this macromolecule.终极放射化学噩梦：在对肉毒杆菌神经毒素A进行放射性碘化时，引入的碘原子本身似乎对这种大分子的生物活性是致命的。
EJNMMI Res. 2015 Feb 19;5:5. doi: 10.1186/s13550-015-0083-5. eCollection 2015.
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