Hoeldtke R D, Cilmi K M, Reichard G A, Boden G, Owen O E
J Lab Clin Med. 1983 May;101(5):772-82.
A noninvasive method is described for assessing the disposition of NE produced by peripheral sympathetic neurons. Total NE production is estimated from integrated NE metabolite excretion. The rate at which NE enters the bloodstream (apparent NE secretion) is estimated by isotope dilution analysis. The rate at which NE is metabolized locally is calculated by subtracting apparent NE secretion from NE production. In 10 normal volunteers, basal NE production by the peripheral sympathetic nervous system was 11.1 +/- 1.0 nmol/m2/min. Apparent NE secretion, by contrast, was only 2.4 +/- 0.18 nmol/m2/min. Our data thus demonstrate that in normal individuals under basal conditions, at least 78% of the NE produced by the sympathetic nervous system undergoes local metabolism and that no more than 22% of NE diffuses into the circulation.
描述了一种用于评估外周交感神经元产生的去甲肾上腺素（NE）处置情况的非侵入性方法。总NE生成量通过整合NE代谢物排泄量来估算。NE进入血液的速率（表观NE分泌）通过同位素稀释分析来估算。NE在局部代谢的速率通过从NE生成量中减去表观NE分泌量来计算。在10名正常志愿者中，外周交感神经系统的基础NE生成量为11.1±1.0 nmol/m²/分钟。相比之下，表观NE分泌量仅为2.4±0.18 nmol/m²/分钟。因此，我们的数据表明，在基础条件下的正常个体中，交感神经系统产生的NE至少78%经历局部代谢，且不超过22%的NE扩散进入循环。
