Steinberg S M, Dehring D J, Gower W R, Vento J M, Lowery B D, Cloutier C T
J Surg Res. 1983 Apr;34(4):298-302. doi: 10.1016/0022-4804(83)90075-6.
Manipulation of prostaglandins (PG) in animal models of sepsis and acute respiratory failure (ARF) is promising. Prostacyclin (PGI2), a short-acting vasodilator, was evaluated in a porcine model of ARF produced by continuous infusion of live Pseudomonas aeruginosa (Ps.). Cardiopulmonary parameters were monitored in three groups of spontaneously breathing animals that received 0.1 micrograms PGI2/kg/min begun 20 min after baseline (Group I); 2 X 10(8) Ps./20 kg/min (Group II); identical Ps. infusion and then PGI2 begun at 20 min (Group III). The decrease in mean arterial blood pressure and cardiac index with Ps. infusion was improved by PGI2 treatment. In Groups II and III, mean pulmonary artery pressure (PAP) doubled (P less than 0.005) and pulmonary vascular resistance (PVR) tripled (P less than 0.01) by 15 min. Both PAP and PVR were decreased significantly with PGI2 treatment. In both Ps. groups, significant hypoxemia occurred. PGI2 improves cardiac output and acts as a pulmonary vasodilator, but does not improve oxygenation in this porcine model of severe ARF.
在脓毒症和急性呼吸衰竭（ARF）动物模型中对前列腺素（PG）进行调控很有前景。前列环素（PGI2）是一种短效血管扩张剂，在通过持续输注活的铜绿假单胞菌（Ps.）建立的猪ARF模型中进行了评估。在三组自主呼吸的动物中监测心肺参数，这三组动物分别为：在基线后20分钟开始接受0.1微克PGI2/千克/分钟的输注（第一组）；接受2×10⁸个Ps./20千克/分钟的输注（第二组）；接受相同的Ps.输注，然后在20分钟时开始输注PGI2（第三组）。PGI2治疗改善了Ps.输注导致的平均动脉血压和心脏指数的下降。在第二组和第三组中，到15分钟时平均肺动脉压（PAP）翻倍（P<0.005），肺血管阻力（PVR）增至三倍（P<0.01）。PGI2治疗使PAP和PVR均显著降低。在两个Ps.组中均出现了明显的低氧血症。在这个严重ARF的猪模型中，PGI2可改善心输出量并起到肺血管扩张剂的作用，但不能改善氧合。
