Dehring D J, Lowery B D, Flynn J, Reitz G, Steinberg S, Carey L C, Cloutier C T
J Trauma. 1983 Aug;23(8):725-9. doi: 10.1097/00005373-198308000-00008.
The effects of indomethacin, a prostaglandin synthesis blocker, were tested in a porcine model of septic acute respiratory failure (ARF) produced by continuous infusion of live Ps. aeruginosa. Control groups received either indomethacin boluses (2 mg/kg) intravenously at 20 and 210 minutes or Ps. aeruginosa infusion (2 X 10(8) CFU/20 kg/min). The treatment group received both continuous Ps. aeruginosa infusion and indomethacin. Indomethacin alone transiently but significantly decreased cardiac indices, heart rate, and PaCO2. With Ps. aeruginosa infusion, significant pulmonary hypertension, hypoxemia, increased intrapulmonary shunt fraction, and systemic hypotension occurred. In this porcine model of septic ARF, indomethacin doubled the survival period and improved cardiopulmonary parameters.
通过持续输注活的铜绿假单胞菌建立猪败血症性急性呼吸衰竭（ARF）模型，测试前列腺素合成阻滞剂吲哚美辛的效果。对照组在第20和210分钟静脉注射吲哚美辛大剂量（2mg/kg），或输注铜绿假单胞菌（2×10⁸CFU/20kg/min）。治疗组同时接受持续的铜绿假单胞菌输注和吲哚美辛治疗。单独使用吲哚美辛可使心脏指数、心率和动脉血二氧化碳分压短暂但显著降低。输注铜绿假单胞菌后，出现了显著的肺动脉高压、低氧血症、肺内分流分数增加和全身低血压。在这个猪败血症性ARF模型中，吲哚美辛使生存期延长了一倍，并改善了心肺参数。
