Fadda F, Argiolas A, Melis M R, De Montis G, Gessa G L
Life Sci. 1983 Mar 28;32(13):1471-7. doi: 10.1016/0024-3205(83)90913-x.
The effect of gamma-butyrolactone (GBL) on voluntary ethanol intake was studied in a group of Wistar rats in which a stable preference had been induced by exposure to increasing ethanol concentrations. These rats drank 60% of their daily fluid intake as 15% ethanol solution, corresponding to about 6 g ethanol/kg/day. GBL, injected intraperitoneally at the dose of 200 mg/kg, twice daily for 3 consecutive days, decreased ethanol intake by about 80% on the days of treatment, but did not reduce total fluid intake. Ethanol intake remained significantly reduced up to the 5th day following cessation of GBL administration. GBL, up to a concentration of 10(-3) M, inhibited neither alcohol-dehydrogenase nor aldehyde-dehydrogenase in rat liver homogenates, nor dopamine-beta-hydroxylase in homogenates of adrenal medulla or hypothalamus of rats. It is suggested that inhibition of firing in dopaminergic neurons mediates the suppressant effect of GBL on ethanol preference.
在一组Wistar大鼠中研究了γ-丁内酯（GBL）对自愿乙醇摄入量的影响，这些大鼠通过暴露于逐渐增加的乙醇浓度已诱导出稳定的偏好。这些大鼠将其每日液体摄入量的60%作为15%乙醇溶液饮用，相当于约6克乙醇/千克/天。以200毫克/千克的剂量腹腔注射GBL，每天两次，连续3天，在治疗期间乙醇摄入量减少了约80%，但总液体摄入量没有减少。在停止给予GBL后的第5天，乙醇摄入量仍显著降低。浓度高达10^(-3) M的GBL既不抑制大鼠肝脏匀浆中的乙醇脱氢酶也不抑制醛脱氢酶，也不抑制大鼠肾上腺髓质或下丘脑匀浆中的多巴胺-β-羟化酶。有人提出，多巴胺能神经元放电的抑制介导了GBL对乙醇偏好的抑制作用。
