Gianutsos G, Moore K E
J Pharmacol Exp Ther. 1978 Dec;207(3):859-69.
Acute injections of baclofen or gamma-butyrolactone (GBL) into mice caused dose-dependent depression of locomotor activity and an elevation of the dopamine content and a reduction of dopamine turnover in the brain. An acute injection of baclofen, but not of GBL, was less effective in producing these effects in mice maintained on a diet containing baclofen for 10 to 12 days. This suggests that baclofen and GBL may influence dopamine neurons by different mechanisms. Acute injections of both baclofen and GBL were less effective in producing behavioral and neurochemical effects in mice pre-treated for 13 days with injections of GBL. Tolerance to the behavioral and neurochemical actions of baclofen and GBL do not appear to be the result of metabolic tolerance but possibly result from changes in the properties of the dopamine neurons.
向小鼠急性注射巴氯芬或γ-丁内酯（GBL）会导致运动活性呈剂量依赖性降低，同时脑内多巴胺含量升高且多巴胺周转率降低。在食用含巴氯芬的饮食10至12天的小鼠中，急性注射巴氯芬而非GBL，产生这些效应的效果较差。这表明巴氯芬和GBL可能通过不同机制影响多巴胺神经元。在预先注射GBL 13天的小鼠中，急性注射巴氯芬和GBL产生行为和神经化学效应的效果均较差。对巴氯芬和GBL行为及神经化学作用的耐受性似乎并非代谢耐受性的结果，而可能是多巴胺神经元特性改变所致。
