Shimizu M, Yasui Y, Matsumoto N
Mutat Res. 1983 Mar;116(3-4):217-38. doi: 10.1016/0165-1218(83)90060-5.
The mutagenicity of 21 chloro- or fluoronitrobenzene compounds and 9 chloro- or fluorobenzene compounds in Salmonella typhimurium (strains TA98, TA1538, TA1537, TA100 and TA1535) was examined. The tests were carried out under the conditions of absence and presence of liver microsomal activation. 15 nitro-group compounds had mutagenic activity; above all, compounds of fluoronitrobenzene were mutagenic for both types of strain. On the other hand, chloronitrobenzene compounds were mutagenic for base-pair substitution strains only. Mutagenic activity was exhibited by all compounds having a chloro or fluoro substituent at the para and ortho position in the nitrobenzene nucleus. All compounds without a nitro substituent showed no mutagenic activity.
检测了21种氯代或氟代硝基苯化合物以及9种氯代或氟代苯化合物在鼠伤寒沙门氏菌（TA98、TA1538、TA1537、TA100和TA1535菌株）中的致突变性。试验在无肝微粒体激活和有肝微粒体激活的条件下进行。15种硝基化合物具有致突变活性；尤其是，氟代硝基苯化合物对两种菌株均具有致突变性。另一方面，氯代硝基苯化合物仅对碱基对置换菌株具有致突变性。在硝基苯核的对位和邻位具有氯或氟取代基的所有化合物均表现出致突变活性。所有没有硝基取代基的化合物均无致突变活性。
