Yoshida D, Fukuhara Y
Mutat Res. 1983 Apr;120(1):7-11. doi: 10.1016/0165-7992(83)90067-2.
Catechol was not mutagenic for Salmonella typhimurium TA98, TA100 or TA1537 in the presence or absence of S9 mix. At the lower level of S9 in the Ames method, the mutagenic activity of benzo[a]pyrene decreased with the increased addition of catechol. When catechol was added to the pre-incubation mixture at a higher concentration than in the conventional Ames method, the mutagenic activity of benzo[a]pyrene increased with the increased addition of catechol. Catechol is believed to be a co-mutagen for benzo[a]pyrene in the presence of a sufficient amount of S9 in the incubation mixture.
在有或没有S9混合液的情况下，儿茶酚对鼠伤寒沙门氏菌TA98、TA100或TA1537均无致突变性。在艾姆斯试验法中较低水平的S9条件下，苯并[a]芘的致突变活性随着儿茶酚添加量的增加而降低。当儿茶酚以高于传统艾姆斯试验法的浓度添加到预孵育混合物中时，苯并[a]芘的致突变活性随着儿茶酚添加量的增加而增加。据信，在孵育混合物中有足够量S9的情况下，儿茶酚是苯并[a]芘的共诱变剂。
