Ris H B, Stahel E, Pittet J F, Friedemann M
Schweiz Med Wochenschr. 1983 Feb 19;113(7):254-8.
Parenteral quinine is the most effective treatment for severe falciparum malaria. It is not easily available in Switzerland and so dangerous delays treating patients may occur. The antiarrhythmic drug quinidine, usually stocked by hospitals, is an alternative drug for malaria treatment. We report the cases of two patients with severe malaria imported from Kenya. They were treated first with intravenous quinidine sulfate over 3 days and for another 4 days with peroral quinidine sulfate. The therapeutic response was excellent. During the 2 months posttherapeutic period no recrudescence of Plasmodium falciparum occurred. 20 mg/kg b.w./die of quinidine given intravenously seems to be an adequate dose in severe falciparum malaria.
肠胃外注射奎宁是治疗重症恶性疟最有效的方法。在瑞士，该药不易获取，因此可能会出现危险的治疗延误情况。医院通常储备的抗心律失常药物奎尼丁是治疗疟疾的替代药物。我们报告了两名从肯尼亚输入的重症疟疾患者的病例。他们首先接受了为期3天的静脉注射硫酸奎尼丁治疗，随后又接受了4天的口服硫酸奎尼丁治疗。治疗反应极佳。在治疗后的2个月内，未出现恶性疟原虫复发的情况。对于重症恶性疟，静脉注射20毫克/千克体重/天的奎尼丁似乎是一个合适的剂量。
