Mukada T, Itasaka K, Miyazaki S, Hirakawa H, Kashiwagura J, Sasaki Y, Andoh S, Shinzawa A, Sendoh F
Tohoku J Exp Med. 1983 Jan;139(1):83-90. doi: 10.1620/tjem.139.83.
An autopsy case of pulmonary hypertension in a 29-year-old Japanese female with macronodular, posthepatic liver cirrhosis and hepatitis-B antigenemia was presented. No recognizable known cardio-pulmonary disease or portal thrombosis was obtained. Hepatitis-B antigen was demonstrated in the cirrhotic hepatocytes by a specific peroxidase antiperoxidase method. Characteristic pulmonary arterial changes including plexiform lesions with varying developmental stages were widely observed throughout the lungs. Complication of these two distinct disease processes seems to be rarely encountered in the literature. Discussion was focused on the possible interrelationship between the liver cirrhosis with hepatitis-B antigenemia and pulmonary hypertension. Proposed were presumptive underlying humoral, particularly immunological, abnormalities common to these diseases rather than mere incidental complications.
本文报告了一例29岁日本女性肺动脉高压尸检病例，该患者患有大结节性肝后性肝硬化及乙肝表面抗原血症。未发现可识别的已知心肺疾病或门静脉血栓形成。采用特异性过氧化物酶抗过氧化物酶法在肝硬化肝细胞中检测到乙肝表面抗原。在整个肺脏广泛观察到特征性的肺动脉改变，包括不同发育阶段的丛状病变。这两种不同疾病过程的并发在文献中似乎很少见。讨论集中在乙肝表面抗原血症肝硬化与肺动脉高压之间可能的相互关系。提出这些疾病共有的潜在体液异常，尤其是免疫异常，而非仅仅是偶然的并发症。
