Asakawa H, Taguchi T, Mori W
Gan. 1976 Jun;67(3):347-53.
Hyperferritinemia in various diseases, mainly hematological, was confirmed by immunological methods. For ferritin detection, anti-human placental ferritin antiserum, anti-human hepatic ferritin antiserum, and anti-human leukemia cell ferritin antiserum were used and the result was compared with each other. Leukemia, malignant lymphoma, multiple myeloma, and aplastic anemia are hematological diseases which showed a positive reaction in this test, among which leukemia showed the highest positivity. Cases of hepatic diseases and non-hematological malignant neoplasms also showed a positive reaction. The positivity was quite low and almost negligible in other diseases and healthy individuals. Anti-human placental ferritin antiserum seemed to be suitable for cancer diagnosis and, antihuman hepatic ferritin antiserum for hepatic diseases. The results of analysis of purified human hepatic and placental ferritins highly suggested the presence of immunological heterogeneities between them. Also, a possibility was pointed out that one of the components of the so-called leukemia-specific antigens might sometimes be the isoferritin of leukemia cells.
通过免疫学方法证实了各种疾病（主要是血液系统疾病）中存在高铁蛋白血症。对于铁蛋白检测，使用了抗人胎盘铁蛋白抗血清、抗人肝铁蛋白抗血清和抗人白血病细胞铁蛋白抗血清，并将结果相互比较。白血病、恶性淋巴瘤、多发性骨髓瘤和再生障碍性贫血是在该检测中呈阳性反应的血液系统疾病，其中白血病的阳性率最高。肝脏疾病和非血液系统恶性肿瘤病例也呈阳性反应。在其他疾病和健康个体中，阳性率相当低，几乎可以忽略不计。抗人胎盘铁蛋白抗血清似乎适用于癌症诊断，抗人肝铁蛋白抗血清适用于肝脏疾病诊断。对纯化的人肝铁蛋白和胎盘铁蛋白的分析结果强烈表明它们之间存在免疫异质性。此外，还指出所谓白血病特异性抗原的成分之一有时可能是白血病细胞的异铁蛋白。
