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New monoclonal antibody enzymoassay for the specific measurement of placental ferritin isotype in hematologic malignancies.

作者信息

Moroz C, Bessler H, Lurie Y, Shaklai M

出版信息

Exp Hematol. 1987 Mar;15(3):258-62.

PMID:3817052
Abstract

A new enzymoimmunoassay, specific for the measurement of placental ferritin (PLF) isotype, has been described. Two monoclonal antibodies (McAbs) with different binding specificities to placental ferritin have been used in this assay. One antibody (CM-G-8) binds to all ferritins, whereas the second (CM-H-9) binds to placental ferritin only. In addition, a second enzymoassay was developed for the measurement of total common serum ferritin using CM-G-8 McAb. Serum levels of total ferritin and PLF were measured in healthy individuals and in patients with lymphoproliferative diseases and multiple myeloma. The majority of normal subjects were deficient in PLF in the serum. Increased serum levels of PLF were observed in patients with Hodgkin's lymphoma and non-Hodgkin's lymphoma of low and intermediate grades, as well as in patients with acute lymphocytic leukemia (ALL). Total ferritin was also elevated in these patients. Chronic lymphocytic leukemia (CLL) and multiple myeloma patients exhibited normal levels of common serum ferritin, whereas PLF in the serum was lacking.

摘要

相似文献

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New monoclonal antibody enzymoassay for the specific measurement of placental ferritin isotype in hematologic malignancies.
Exp Hematol. 1987 Mar;15(3):258-62.
2
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引用本文的文献

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Neoplasia. 2014 Sep;16(9):741-50. doi: 10.1016/j.neo.2014.08.005.
2
Antibodies to placental immunoregulatory ferritin with transfer of polyclonal lymphocytes arrest MCF-7 human breast cancer growth in a nude mouse model.具有多克隆淋巴细胞转移的胎盘免疫调节铁蛋白抗体可抑制裸鼠模型中MCF-7人乳腺癌的生长。
Neoplasia. 2007 Jun;9(6):487-94. doi: 10.1593/neo.07259.
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Growth stimulation of ferritin of human leukemia cells in vitro.
人白血病细胞铁蛋白在体外的生长刺激作用
J Cancer Res Clin Oncol. 1995;121(2):76-8. doi: 10.1007/BF01202216.
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The immunosuppressive human placental ferritin subunit p43 is produced by activated CD4+ lymphocytes.免疫抑制性人胎盘铁蛋白亚基p43由活化的CD4 +淋巴细胞产生。
Clin Diagn Lab Immunol. 1995 Mar;2(2):225-6. doi: 10.1128/cdli.2.2.225-226.1995.
5
Difference in the placental ferritin levels measured by a specific monoclonal antibody enzymoassay in preterm and term delivery.通过特定单克隆抗体酶联免疫吸附测定法测量的早产和足月分娩时胎盘铁蛋白水平的差异。
Clin Exp Immunol. 1987 Sep;69(3):702-6.
6
T-cell mitogenesis stimulates the synthesis of a mRNA species coding for a 43-kDa peptide reactive with CM-H-9, a monoclonal antibody specific for placental isoferritin.T细胞有丝分裂刺激了一种mRNA的合成，该mRNA编码一种与CM-H-9反应的43 kDa肽，CM-H-9是一种针对胎盘异铁蛋白的单克隆抗体。
Proc Natl Acad Sci U S A. 1989 May;86(9):3282-5. doi: 10.1073/pnas.86.9.3282.
7
Placental isoferritin as a physiological downregulator of cellular immunoreactivity during pregnancy.胎盘铁蛋白作为孕期细胞免疫反应的生理性下调因子。
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Breast Cancer Res Treat. 1991 Nov;19(3):283-8. doi: 10.1007/BF01961165.