单纯性A组链球菌性咽炎患者及急性链球菌感染后肾小球肾炎患者的循环免疫复合物

Circulating immune complexes in patients with uncomplicated group A streptococcal pharyngitis and patients with acute poststreptococcal glomerulonephritis.

作者信息

Yoshizawa N, Treser G, McClung J A, Sagel I, Takahashi K

出版信息

Am J Nephrol. 1983 Jan-Feb;3(1):23-9. doi: 10.1159/000166682.

Abstract

To investigate the role of circulating immune complexes (CIC) in the pathogenesis of acute poststreptococcal glomerulonephritis (AGN), sera were obtained serially from 13 patients with biopsy-proven AGN, 16 patients with group A streptococcal infection, and 20 age- and sex-matched controls. Samples were analysed for Clq-binding activity (Clq-BA), levels of IgG, IgA, IgM, C3 and C4, and antibody titres to streptococcal enzymes. Significant elevation of Clq-BA was observed in 11 patients (84.5%) with AGN and 7 patients (44%) with streptococcal infection alone. The data suggest that CIC do not necessarily cause glomerular damage, but rather represent a systemic inflammatory response in patients with group A streptococcal infection.

摘要

为研究循环免疫复合物（CIC）在急性链球菌感染后肾小球肾炎（AGN）发病机制中的作用，我们连续采集了13例经活检证实为AGN的患者、16例A组链球菌感染患者以及20例年龄和性别匹配的对照者的血清。对样本进行了Clq结合活性（Clq-BA）、IgG、IgA、IgM、C3和C4水平以及抗链球菌酶抗体滴度的分析。在11例（84.5%）AGN患者和7例（44%）仅链球菌感染患者中观察到Clq-BA显著升高。数据表明，CIC不一定会导致肾小球损伤，而是代表A组链球菌感染患者的全身炎症反应。