Mezzano S, Olavarría F, Ardiles L, López M I
Clin Nephrol. 1986 Aug;26(2):61-5.
In an attempt to further study the possible contribution of circulating immune complexes (CIC) in the pathogenesis of acute poststreptococcal glomerulonephritis, 61 patients with APSGN were studied during the first three weeks of the disease, and 13 patients with noncomplicated streptococcal impetigo as a control group. C1q solid phase ELISA and Conglutinin (K) solid phase ELISA were used to measure the levels of immune complexes. The incidence of CIC in a single serum sample from patients with APSGN was 48%. Elevated levels of immune complexes were found in 46% of the patients with streptococcal impetigo. The absolute levels of CIC were comparable in both groups of patients. No correlation was found among the presence of CIC and the clinical, immunoserological or pathological findings of the disease. Our results do not support the hypothesis that trapping of the circulating immune complexes play an important role on the renal injury poststreptococcal infection. Instead, we suggest that CIC are an epiphenomena present in APSGN, and may represent rather a systemic inflammatory immune response in patients with group A streptococcal infection.
为了进一步研究循环免疫复合物（CIC）在急性链球菌感染后肾小球肾炎发病机制中可能的作用，我们对61例急性链球菌感染后肾小球肾炎患者在疾病的前三周进行了研究，并将13例无并发症的链球菌性脓疱病患者作为对照组。采用C1q固相酶联免疫吸附测定法（ELISA）和胶固素（K）固相ELISA法检测免疫复合物水平。急性链球菌感染后肾小球肾炎患者单次血清样本中CIC的发生率为48%。46%的链球菌性脓疱病患者免疫复合物水平升高。两组患者CIC的绝对水平相当。未发现CIC的存在与疾病的临床、免疫血清学或病理结果之间存在相关性。我们的结果不支持循环免疫复合物的沉积在链球菌感染后肾脏损伤中起重要作用这一假说。相反，我们认为CIC是急性链球菌感染后肾小球肾炎中出现的一种附带现象，可能代表A组链球菌感染患者的一种全身性炎症免疫反应。
