4例婴儿t(4;11)急性白血病及其髓单核细胞性质
Four cases of t(4;11) acute leukemia and its myelomonocytic nature in infants.
作者信息
Nagasaka M, Maeda S, Maeda H, Chen H L, Kita K, Mabuchi O, Misu H, Matsuo T, Sugiyama T
出版信息
Blood. 1983 Jun;61(6):1174-81.
Four cases of acute infantile leukemia with translocation (4;11) (q21;q23) are reported. Although leukemia with this chromosomal abnormality has been classified as L2 acute lymphoblastic leukemia by the FAB classification, two of our cases appeared to be of myelomonocyte origin as demonstrated by cytochemical, immunologic, and electron microscopic studies and differentiation induction by 12-tetradecanoyl-phorbol-13-acetate and methylformamide. This chromosomal change is associated with poor prognosis.
报告了4例伴有（4；11）（q21；q23）易位的急性婴儿白血病。尽管根据FAB分类，伴有这种染色体异常的白血病已被归类为L2型急性淋巴细胞白血病，但我们的2例病例经细胞化学、免疫学和电子显微镜研究以及由12 - 十四酰佛波醇 - 13 - 乙酸酯和甲酰胺诱导分化显示，似乎起源于髓单核细胞。这种染色体改变与预后不良相关。
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