急性白血病中6号与11号染色体易位的独特临床特征及预后意义
Unique clinical features and prognostic significance of the translocation (6;11) in acute leukemia.
作者信息
Welborn J L, Jenks H M, Hagemeijer A
机构信息
Department of Internal Medicine, University of California, Davis, Sacramento 95816.
出版信息
Cancer Genet Cytogenet. 1993 Feb;65(2):125-9. doi: 10.1016/0165-4608(93)90220-g.
A translocation (6;11)(q26-27;q23) was detected in four male patients diagnosed with acute T-cell lymphoblastic leukemia and acute myelomonocytic and monocytic leukemias. This acquired reciprocal translocation appears to be associated with acute leukemias in young men who present clinically with localized infection, and a moderate leukocytosis. There was a poor response to antileukemic chemotherapy and a short overall survival. Aggressive treatment strategies should be considered in the treatment of these high-risk leukemias.
在4例被诊断为急性T细胞淋巴细胞白血病、急性粒单核细胞白血病和单核细胞白血病的男性患者中检测到一种(6;11)(q26 - 27;q23)易位。这种获得性相互易位似乎与临床出现局部感染和中度白细胞增多的年轻男性急性白血病有关。抗白血病化疗反应不佳，总生存期短。在治疗这些高危白血病时应考虑积极的治疗策略。
Zotero 插件