急性非淋巴细胞白血病中的易位t(8;16)(p11;p13)：两例新病例报告及文献复习
Translocation t(8;16)(p11;p13) in acute non-lymphocytic leukemia: report on two new cases and review of the literature.
作者信息
Velloso E R, Mecucci C, Michaux L, Van Orshoven A, Stul M, Boogaerts M, Bosly A, Cassiman J J, Van Den Berghe H
机构信息
Center for Human Genetics, University of Louvain, Leuven, Belgium.
出版信息
Leuk Lymphoma. 1996 Mar;21(1-2):137-42. doi: 10.3109/10428199609067591.
Two new cases of t(8;16)(p11;p13) in acute nonlymphocytic leukemia (ANLL) are described. These two patients in addition to the 34 previously described, showed a striking association with myelomonocytic (M4) or monocytic (M5) leukemia, extramedullary infiltration, erythrophagocytosis and disseminated intravascular coagulation. One of our patients showed a TCRbeta gene rearrangement. Alltogether 36 cases of t(8;16) ANLL have been documented until today. We here review their clinical and cytogenetic features.
本文描述了两例急性非淋巴细胞白血病（ANLL）中出现t(8;16)(p11;p13)的新病例。这两名患者除了先前描述的34例之外，显示出与骨髓单核细胞性（M4）或单核细胞性（M5）白血病、髓外浸润、噬红细胞作用和弥散性血管内凝血有显著关联。我们的一名患者显示出TCRβ基因重排。截至目前，共记录了36例t(8;16) ANLL病例。我们在此回顾其临床和细胞遗传学特征。
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