Luther E R, Gray J H, Young D, Gouin J A, Lorrain J
Can Med Assoc J. 1983 May 15;128(10):1189-91.
A multicentre, randomized, double-blind trial compared the efficacy and safety of and tolerance to natural and synthetically produced prostaglandin E2 tablets in the induction of labour in 202 women. The compounds were similarly effective, inducing labour in approximately 66% of patients. The total dose required and the interval between induction and delivery were similar in the two groups, as were the Apgar scores at 1 and 5 minutes and the incidence of maternal and fetal side effects.
一项多中心、随机、双盲试验比较了天然和合成前列腺素E2片剂在202名妇女引产中的疗效、安全性和耐受性。两种化合物效果相似,约66%的患者引产成功。两组所需的总剂量、引产至分娩的间隔时间、1分钟和5分钟时的阿氏评分以及母婴副作用发生率相似。