Nelson G H, Bryans C I
Am J Obstet Gynecol. 1978 Nov 15;132(6):642-8. doi: 10.1016/0002-9378(78)90857-8.
There were 153 oral prostaglandin (PG) E2 inductions attempted in 149 patients. For various reasons nine cases were dropped from the study. Of the remaining 144 induction attempts, 96 were judged successful, with a success rate of 67 per cent. Details of these inductions are presented, including summaries of three patients with uterine hypertonus and three with uterine hyperstimulation. As a rule, the labor pattern established with oral PGE2 was effective and indistinguishable from normal spontaneous labor. After review of the data we feel that induction of labor with oral PGE2 is no more hazardous to mother or infant than with other oxytocic agents. In our opinion oral PGE2 offers the obstetrician an additional means for induction of labor in normal and high-risk pregnancies. The need for close observation of the progress of labor during PGE2 inductions is emphasized.
对149例患者尝试进行了153次口服前列腺素（PG）E2引产。由于各种原因，9例患者退出研究。在其余144次引产尝试中，96次被判定成功，成功率为67%。本文介绍了这些引产的详细情况，包括3例子宫张力过高和3例子宫过度刺激患者的摘要。通常，口服PGE2建立的产程有效，与正常自然产程无异。在对数据进行审查后，我们认为口服PGE2引产对母亲或婴儿的危害并不比其他催产剂更大。我们认为口服PGE2为产科医生在正常和高危妊娠中引产提供了一种额外的方法。强调了在PGE2引产过程中密切观察产程进展的必要性。
