Alexander E L, Provost T T
J Invest Dermatol. 1983 May;80(5):386-91. doi: 10.1111/1523-1747.ep12552002.
Twenty-two symptomatic primary Sjögren's syndrome patients with clinical and histologic evidence of skin disease were studied. Purpura and urticaria were the most frequent clinical cutaneous manifestations. Most of these lesions were associated with a leukocytoclastic angiitis and, less commonly, a mononuclear (lymphocytic) vasculitis. Two main cutaneous syndromes were identified whose clinical, serologic, and histopathologic features were indistinguishable from Waldenström's benign hyperglobulinemic purpura and hypocomplementemic urticaria-like vasculitis. Eighty-four percent of primary Sjögren's syndrome patients with vasculitis demonstrated anti-Ro(SSA) antibodies. Thus, purpura and urticaria may reflect cutaneous vasculitis occurring in the clinical setting of Sjögren's syndrome.
对22例有皮肤疾病临床和组织学证据的有症状的原发性干燥综合征患者进行了研究。紫癜和荨麻疹是最常见的临床皮肤表现。这些病变大多与白细胞破碎性血管炎相关，较少与单核细胞（淋巴细胞）血管炎相关。确定了两种主要的皮肤综合征，其临床、血清学和组织病理学特征与瓦尔登斯特伦良性高球蛋白血症性紫癜和低补体血症性荨麻疹样血管炎无法区分。84%患有血管炎的原发性干燥综合征患者表现出抗Ro（SSA）抗体。因此，紫癜和荨麻疹可能反映了干燥综合征临床背景下发生的皮肤血管炎。
