前列环素在人、兔和大鼠血浆中的稳定性差异。

Differences in the stability of prostacyclin in human, rabbit and rat plasma.

作者信息

El Tahir K E, Williams K I, Betteridge D J

出版信息

Prostaglandins Leukot Med. 1983 Feb;10(2):109-14. doi: 10.1016/s0262-1746(83)80001-8.

PMID:6342001

Abstract

Prostacyclin (PGI2) is a potent vasodilator and inhibitor of platelet aggregation, however, its half-life in aqueous solutions at neutral or acid pH is very short. In this study we have investigated the stability of PGI2 in plasma from different species and have demonstrated that the half-life of the anti-aggregatory and the hypotensive activity of PGI2 is considerably prolonged in human plasma. Interestingly the activity of PGI2 was not maintained on incubation in rat or rabbit plasma indicating that the stabilising factor may be confined to human plasma. Whether such stabilisation prolongs the half-life of PGI2 in the human circulation merits investigation.

摘要

前列环素（PGI2）是一种强效血管舒张剂和血小板聚集抑制剂，然而，它在中性或酸性pH值的水溶液中的半衰期非常短。在本研究中，我们研究了PGI2在不同物种血浆中的稳定性，并证明PGI2的抗聚集和降压活性在人血浆中的半衰期显著延长。有趣的是，PGI2在大鼠或兔血浆中孵育时活性无法维持，这表明稳定因子可能仅限于人血浆。这种稳定作用是否会延长PGI2在人体循环中的半衰期值得研究。