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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hutchinson J S, Mendelsohn F A

Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):555-8. doi: 10.1111/j.1440-1681.1980.tb00110.x.

The hypotensive response to captopril in anaesthetized spontanously hypertensive rats (SHR) is not modified by bilateral nephrectomy performed 1 or 24 h previously. 2. Intracerebroventricular injection (i.c.v.) of captopril (2 mg kg-1) significantly lowered blood pressure of conscious SHR over a 7-h period of observation but there was no significant blood pressure response to i.c.v. vehicle, or to intravenous captopril (2 mg kg-1) in SHR. 3. There was no significant blood pressure response to captopril (2 mg kg-1) i.c.v. in the normotensive Wistar Kyoto controls (NT-WK). 4. These results indicate that captopril can lower the blood pressure of SHR by mechanisms independent of the kidneys or the circulating renin-angiotensin system. 5. The hypotensive effect of central captopril in SHR but not in the NT-WK suggests biochemical differences between the brains of the two rat strains.

在麻醉的自发性高血压大鼠（SHR）中，卡托普利的降压反应不受1小时或24小时前进行的双侧肾切除术的影响。2. 脑室内注射（i.c.v.）卡托普利（2毫克/千克）在7小时的观察期内显著降低了清醒SHR的血压，但SHR对i.c.v.溶媒或静脉注射卡托普利（2毫克/千克）没有明显的血压反应。3. 在正常血压的Wistar Kyoto对照大鼠（NT-WK）中，i.c.v.注射卡托普利（2毫克/千克）没有明显的血压反应。4. 这些结果表明，卡托普利可通过独立于肾脏或循环肾素-血管紧张素系统的机制降低SHR的血压。5. 中枢给予卡托普利对SHR有降压作用，但对NT-WK没有，这表明两种大鼠品系的大脑存在生化差异。

Hutchinson J S, Mendelsohn F A

Clin Exp Pharmacol Physiol. 1980 Sep-Oct;7(5):555-8. doi: 10.1111/j.1440-1681.1980.tb00110.x.

The hypotensive response to captopril in anaesthetized spontanously hypertensive rats (SHR) is not modified by bilateral nephrectomy performed 1 or 24 h previously. 2. Intracerebroventricular injection (i.c.v.) of captopril (2 mg kg-1) significantly lowered blood pressure of conscious SHR over a 7-h period of observation but there was no significant blood pressure response to i.c.v. vehicle, or to intravenous captopril (2 mg kg-1) in SHR. 3. There was no significant blood pressure response to captopril (2 mg kg-1) i.c.v. in the normotensive Wistar Kyoto controls (NT-WK). 4. These results indicate that captopril can lower the blood pressure of SHR by mechanisms independent of the kidneys or the circulating renin-angiotensin system. 5. The hypotensive effect of central captopril in SHR but not in the NT-WK suggests biochemical differences between the brains of the two rat strains.

在麻醉的自发性高血压大鼠（SHR）中，卡托普利的降压反应不受1小时或24小时前进行的双侧肾切除术的影响。2. 脑室内注射（i.c.v.）卡托普利（2毫克/千克）在7小时的观察期内显著降低了清醒SHR的血压，但SHR对i.c.v.溶媒或静脉注射卡托普利（2毫克/千克）没有明显的血压反应。3. 在正常血压的Wistar Kyoto对照大鼠（NT-WK）中，i.c.v.注射卡托普利（2毫克/千克）没有明显的血压反应。4. 这些结果表明，卡托普利可通过独立于肾脏或循环肾素-血管紧张素系统的机制降低SHR的血压。5. 中枢给予卡托普利对SHR有降压作用，但对NT-WK没有，这表明两种大鼠品系的大脑存在生化差异。