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链球菌感染后型快速进行性肾小球肾炎的抗凝与免疫抑制治疗(作者译)

[Anticoagulation and immunosuppression in rapidly progressive glomerulonephritis of poststreptococcal type (author's transl)].

作者信息

Kampf D, Höfer W, Misgeld V

出版信息

Med Klin. 1978 Mar 17;73(11):395-400.

PMID:634203
Abstract

In the majority of cases acute poststreptococcal glomerulonephritis is characterized by a good prognosis. Only relatively rare courses of this disease with clinical symptoms of rapid progressive glomerulonephritis and morphological signs of extracapillary glomerulonephritis together with crescent formation are sometimes prone to an infavorable outcome. A widely accepted medication does not exist up to now. Our own observations including clinical and morphological follow up studies are suggesting a combination of anticoagulants and immunosuppressive drugs. Indication and usefullness of that regimen are discussed.

摘要

在大多数情况下,急性链球菌感染后肾小球肾炎的特点是预后良好。只有相对罕见的该疾病病程,伴有快速进行性肾小球肾炎的临床症状以及毛细血管外肾小球肾炎的形态学表现和新月体形成,有时容易出现不良结局。到目前为止,尚无广泛接受的药物治疗方法。我们自己的观察,包括临床和形态学随访研究,提示抗凝剂和免疫抑制药物联合使用。本文讨论了该治疗方案的适应证和有效性。

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