Stanciu L, Urcan S, Părău N, Radu D, Itu I, Georoceanu A
Med Interne. 1983 Jan-Mar;21(1):19-22.
Blood lymphocyte subpopulations were investigated in 50 patients with allergic diseases (38 with allergic rhinitis and 12 with allergic bronchial asthma). The total T lymphocyte (Tt) count (E rosette test), the active T lymphocyte (Ta) count (active E rosette test) and the B lymphocyte count (EAC rosette test) were determined and the results were correlated with: 1) lymphocyte sensitization in vitro to different allergens and to PPD; 2) circulating immune complexes; 3) serum histaminopexic capacity. In allergic rhinites a decrease of Tt and B lymphocytes and an increase of Ta lymphocytes was observed. In allergic bronchial asthma the Tt lymphocyte were found reduced. Lymphocyte reactivity to PPD in vitro was present in 100% of the cases and in vitro lymphocyte sensitivity to several allergens was observed in most of the cases. The histaminopexic capacity was absent or low in 75% of the patients with allergic rhinitis and in 66.6% of the patients with allergic bronchial asthma. The involvement of cellular mediated immunity in allergic diseases is discussed.
对50例过敏性疾病患者（38例过敏性鼻炎患者和12例过敏性支气管哮喘患者）的血液淋巴细胞亚群进行了研究。测定了总T淋巴细胞（Tt）计数（E玫瑰花结试验）、活性T淋巴细胞（Ta）计数（活性E玫瑰花结试验）和B淋巴细胞计数（EAC玫瑰花结试验），并将结果与以下各项进行关联：1）淋巴细胞在体外对不同变应原和PPD的致敏作用；2）循环免疫复合物；3）血清组胺结合能力。在过敏性鼻炎患者中，观察到Tt和B淋巴细胞减少，Ta淋巴细胞增加。在过敏性支气管哮喘患者中，发现Tt淋巴细胞减少。100%的病例中存在淋巴细胞对PPD的体外反应性，大多数病例中观察到淋巴细胞对几种变应原的体外敏感性。75%的过敏性鼻炎患者和66.6%的过敏性支气管哮喘患者的组胺结合能力缺乏或较低。文中讨论了细胞介导免疫在过敏性疾病中的作用。
