甲基多巴与拉贝洛尔治疗高血压的对比研究。
A comparative study of methyldopa and labetalol in the treatment of hypertension.
作者信息
Sanders G L, Davies D M, Gales G M, Rao J G, Rawlins M D, Routledge P A
出版信息
Br J Clin Pharmacol. 1979;8(Suppl 2):149S-151S.
Abstract
1 Twenty patients with essential hypertension completed a double-blind, dose-tritrated, cross-over comparison of methyldopa and labetalol. 2 Average lying BPs (systolic/diastolic) were reduced by 28/15 mmHg with methyldopa and by 23/15 mmHg with labetalol. 3 Average standing BPs (systolic/diastolic) were reduced by 29/14 mmHg with methyldopa and by 29/15 mmHg with labetalol. 4 Both lying and standing heart rates were reduced with labetalol. 5 It is concluded that the antihypertensive properties of labetalol and methyldopa are similar but that larger patient populations are needed to study the relative incidence of subjective adverse effects.
摘要
- 二十名原发性高血压患者完成了甲基多巴和拉贝洛尔的双盲、剂量滴定、交叉对照比较。2. 甲基多巴使平均卧位血压（收缩压/舒张压）降低28/15 mmHg，拉贝洛尔使其降低23/15 mmHg。3. 甲基多巴使平均立位血压（收缩压/舒张压）降低29/14 mmHg，拉贝洛尔使其降低29/15 mmHg。4. 拉贝洛尔使卧位和立位心率均降低。5. 得出的结论是，拉贝洛尔和甲基多巴的降压特性相似，但需要更大规模的患者群体来研究主观不良反应的相对发生率。
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A comparative study of methyldopa and labetalol in the treatment of hypertension.甲基多巴与拉贝洛尔治疗高血压的对比研究。
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Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):783-7.
4
Controlled comparison of labetalol and propranolol in the management of severe hypertension.拉贝洛尔与普萘洛尔治疗重度高血压的对照比较。
Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):777-82.
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Am J Cardiol. 1978 Mar;41(3):570-6. doi: 10.1016/0002-9149(78)90017-6.
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