Hanley S P, Hughes J
Thromb Haemost. 1983 Feb 28;49(1):51-2.
Ex vivo venous prostacyclin synthesis was measured in 24 patients who received no medication, or a single oral dose of aspirin 300 mg, sodium salicylate, 500 mg, or a combination of sodium salicylate 500 mg followed by aspirin 300 mg 1 1/2 or 3 hr later. Aspirin alone substantially reduced PGI2 synthesis but sodium salicylate alone had no effect. Sodium salicylate administration prior to aspirin did not reverse the inhibitory effect of aspirin on PGI2 synthesis.
在24名未接受任何药物治疗、或单次口服300毫克阿司匹林、500毫克水杨酸钠、或先口服500毫克水杨酸钠1.5或3小时后再口服300毫克阿司匹林的患者中，对离体静脉前列环素的合成进行了测定。单独使用阿司匹林可显著降低前列环素（PGI2）的合成，但单独使用水杨酸钠则无此作用。在服用阿司匹林之前给予水杨酸钠并不能逆转阿司匹林对前列环素合成的抑制作用。
