Ritter J M, Ongari M A, Orchard M A, Lewis P J
Thromb Haemost. 1983 Feb 28;49(1):58-60.
Fresh aortic rings incubated in serum produce more 6-oxo-PGF1 alpha, the stable hydrolysis product of prostacyclin, than in plasma or buffer. A method is described of recovering this stimulatory activity from a dialysate of serum, showing that the activity is due to a prostacyclin stimulating factor. This factor is formed during coagulation initiated by the intrinsic pathway but not by the extrinsic pathway or by thrombin. By contrast with a previously described plasma factor, the activity of the prostacyclinstimulating factor in serum is not greater in serum from patients with renal failure than from healthy controls. The stimulating factor is antagonised by heparin, but differs in other ways from previously described platelet derived stimulating factor(s).
与在血浆或缓冲液中孵育相比，在血清中孵育的新鲜主动脉环产生更多的6-氧代前列环素F1α（前列环素的稳定水解产物）。本文描述了一种从血清透析液中回收这种刺激活性的方法，表明该活性归因于一种前列环素刺激因子。该因子在内源性途径启动的凝血过程中形成，而非外源性途径或凝血酶启动的凝血过程。与先前描述的血浆因子不同，肾衰竭患者血清中前列环素刺激因子的活性并不高于健康对照者血清中的活性。该刺激因子可被肝素拮抗，但在其他方面与先前描述的血小板衍生刺激因子不同。
