Paerregaard A, Hendel L, Schultz-Larsen K, Tobiasen K, Mosbech J
Acta Med Scand. 1983;213(3):195-8. doi: 10.1111/j.0954-6820.1983.tb03716.x.
Fifty-eight adult outpatients with endoscopically verified gastric, prepyloric or duodenal ulcers completed a double-blind trial of treatment with either cimetidine, 1 g daily, plus propantheline, 45 mg daily (group A) or cimetidine, 1 g daily, plus placebo (group B). After neither three nor six weeks of treatment was there any significant difference between the two groups with regard to ulcer healing or symptomatic relief. The ulcers of 22 (79%) of the 28 patients in group A and 25 (83%) of the 30 patients in group B were healed after six weeks, and 93% of the patients in both groups became painfree. We were thus not able to show any advantage in combining cimetidine treatment for ulcer healing with low-dose propantheline. In a small open trial the patients with healed ulcers received prophylactic treatment for 12 months with 1) cimetidine 800 mg daily, 2) cimetidine 400 mg at bedtime plus propantheline 45 mg daily or 3) propantheline 90 mg daily. No significant differences were found between the ulcer recurrence rates, but it cannot be excluded that a larger number of patients in each group might have yielded real differences.
58例经内镜证实患有胃溃疡、幽门管溃疡或十二指肠溃疡的成年门诊患者完成了一项双盲治疗试验，一组患者每日服用1克西咪替丁加45毫克溴丙胺太林（A组），另一组患者每日服用1克西咪替丁加安慰剂（B组）。治疗3周和6周后，两组在溃疡愈合或症状缓解方面均无显著差异。A组28例患者中有22例（79%）的溃疡在6周后愈合，B组30例患者中有25例（83%）的溃疡愈合，两组中93%的患者疼痛消失。因此，我们未能证明西咪替丁联合小剂量溴丙胺太林治疗溃疡愈合有任何优势。在一项小型开放试验中，溃疡已愈合的患者接受了为期12个月的预防性治疗，治疗方案分别为：1）每日服用800毫克西咪替丁；2）睡前服用400毫克西咪替丁加每日服用45毫克溴丙胺太林；3）每日服用90毫克溴丙胺太林。溃疡复发率之间未发现显著差异，但不能排除每组中更多患者可能会产生实际差异的情况。
