Morgan A G, Pacsoo C, McAdam W A
Gut. 1985 Dec;26(12):1377-9. doi: 10.1136/gut.26.12.1377.
In a double blind endoscopically controlled study, 100 patients with gastric ulcers were treated with either ranitidine or ranitidine plus Caved-S. On single therapy, 58% of ulcers were healed at four weeks, 92% at eight weeks and 96% at 12 weeks. Combination therapy did not alter the healing rate, nor improve on the control of dyspeptic symptoms. No difference in healing rate was found between good and poor drug compliance patients. This suggests that ranitidine may be equally effective at lower dosages. Thirty seven patients had developed their ulcer while taking non-steroidal anti-inflammatory drugs. These patients were mainly elderly women who had a higher risk of bleeding (p = 0.006) from a large ulcer (p = 0.009).
在一项双盲内镜对照研究中，100例胃溃疡患者接受雷尼替丁或雷尼替丁加Caved-S治疗。单药治疗时，4周时58%的溃疡愈合，8周时92%愈合，12周时96%愈合。联合治疗未改变愈合率，也未改善消化不良症状的控制。药物依从性好和差的患者之间愈合率无差异。这表明雷尼替丁在较低剂量时可能同样有效。37例患者在服用非甾体抗炎药时发生溃疡。这些患者主要是老年女性，大溃疡出血风险较高（p = 0.006），大溃疡发生率也较高（p = 0.009）。
