Andlaw R J, Palmer J D, King J, Kneebone S B
Community Dent Oral Epidemiol. 1983 Jun;11(3):143-7. doi: 10.1111/j.1600-0528.1983.tb01375.x.
The caries-preventive effects of two toothpastes were tested in a 3-year clinical trial involving 1319 children aged 11-13 years. The test toothpastes were: 1) a low abrasion paste containing 0.8% sodium monofluorophosphate (MFP), and 2) a paste containing 3% sodium trimetaphosphate (TMP). The control toothpaste was a conventional, moderately abrasive paste containing 0.8% sodium monofluorophosphate. The children were examined clinically and radiologically each year. Toothpaste was supplied to the children's homes, and its use was unsupervised. Caries increments after 3 years, in terms of DMF teeth and DMF surfaces, showed no significant differences between the MFP test group (444 children) and the MFP control group (450 children). However, the TMP test group (425 children) had significantly higher caries increments than the MFP control group. All three groups of children showed some improvement in oral hygiene and in gingival health, but there were no significant differences between the groups.
在一项涉及1319名11至13岁儿童的为期3年的临床试验中，测试了两种牙膏的防龋效果。测试牙膏分别为：1）一种含0.8%单氟磷酸钠（MFP）的低摩擦牙膏，以及2）一种含3%三聚偏磷酸钠（TMP）的牙膏。对照牙膏是一种含0.8%单氟磷酸钠的传统中度摩擦牙膏。每年对儿童进行临床和放射学检查。牙膏被送到孩子们家中，且使用情况无人监督。3年后，就龋失补牙数（DMF牙）和龋失补牙面数（DMF面）而言，MFP测试组（444名儿童）和MFP对照组（450名儿童）之间的龋增量无显著差异。然而，TMP测试组（425名儿童）的龋增量显著高于MFP对照组。所有三组儿童的口腔卫生和牙龈健康均有一定改善，但组间无显著差异。
