Cahen P M, Frank R M, Turlot J C, Jung M T
Community Dent Oral Epidemiol. 1982 Oct;10(5):238-41. doi: 10.1111/j.1600-0528.1982.tb00386.x.
A randomized, double blind clinical trial of the caries inhibition effects of dentifrices containing respectively monofluorophosphate and amine fluoride was performed. A third control group used a toothpaste without fluoride. A total number of 2008 schoolchildren ranging in age from 6 to 8 years and living in Strasbourg (France) participated in this study. After a baseline examination three groups were constructed with the block randomization technic. The caries inhibition effects of the three dental pastes were compared after 3 years of unsupervised use. The monofluorophosphate dentifrice showed a reduction of 7.02% for DMFT, 5.17% for DMFS and 25.26% for the df rate. The reduction of amine fluoride dentifrice caries was respectively 21.62% for DMFT, 20.94% for DMFS and 48.66% for the df rate.
开展了一项随机双盲临床试验，以研究分别含单氟磷酸钠和氟化胺的牙膏对龋齿的抑制作用。第三组为对照组，使用不含氟的牙膏。共有2008名年龄在6至8岁、居住在法国斯特拉斯堡的学童参与了这项研究。在进行基线检查后，采用区组随机化技术将他们分为三组。在无监督使用三年后，比较了三种牙膏对龋齿的抑制效果。含单氟磷酸钠的牙膏使恒牙龋失补牙面数（DMFT）降低了7.02%，恒牙龋失补牙面数（DMFS）降低了5.17%，龋面充填构成比（df率）降低了25.26%。含氟化胺的牙膏对龋齿的降低率分别为：DMFT降低21.62%，DMFS降低20.94%，df率降低48.66%。
