环孢素可促进B细胞膜免疫球蛋白帽形成。
Cyclosporine facilitates B-cell membrane immunoglobulin capping.
作者信息
Mosbach-Ozmen L, Humez S, Koponen M, Fonteneau P, Loor F
出版信息
Immunology. 1986 Apr;57(4):573-7.
Abstract
The immunomodulatory molecule cyclosporine was found to cause an early acceleration of the capping of mouse B-cell membrane immunoglobulin. This was most marked when the capping process was slightly retarded by keeping the cells at 32 degrees. This is a sign that the drug can cause B-cell membrane alterations. At lower drug doses they might not be as easily detected, but are nevertheless sufficient to inhibit the activation of some B cells by membrane immunoglobulin clustering.
摘要
免疫调节分子环孢素被发现可导致小鼠B细胞膜免疫球蛋白帽化的早期加速。当通过将细胞保持在32摄氏度使帽化过程略有延迟时，这种加速最为明显。这表明该药物可引起B细胞膜改变。在较低的药物剂量下，这些改变可能不太容易被检测到，但仍然足以通过膜免疫球蛋白聚集抑制一些B细胞的活化。
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Effect of cyclosporin A on the induction and activation of B memory cells by thymus-independent antigens in mice.环孢素A对小鼠中胸腺非依赖性抗原诱导和激活B记忆细胞的影响。
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Cytoplasmic lipid droplets as the possible eventual cellular fate of active forms of cyclosporin.细胞质脂滴作为环孢菌素活性形式可能的最终细胞归宿。
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10
Activation and proliferation signals in mouse B cells. I. A comparison of the capacity of anti-Ig antibodies or phorbol myristic acetate to activate B cells from CBA/N or normal mice into G1.小鼠B细胞中的激活和增殖信号。I. 抗Ig抗体或佛波醇肉豆蔻酸酯激活CBA/N小鼠或正常小鼠B细胞进入G1期能力的比较。
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