辐射诱导大鼠前列腺素排泄的变化。
Radiation-induced alterations in prostaglandin excretion in the rat.
作者信息
Donlon M, Steel L, Helgeson E A, Shipp A, Catravas G N
出版信息
Life Sci. 1983 Jun 6;32(23):2631-9. doi: 10.1016/0024-3205(83)90354-5.
PMID:6343746
Abstract
Dose-related alterations in the levels of prostaglandins (PGF2 alpha and PGE) and thromboxane B2 (TxB2) were observed in the urine of unanesthetized rats following whole-body gamma radiation. Exposure doses of 100 and 900 rads resulted in significant changes in urinary levels of these cyclooxygenase products. These findings suggest the potential use of radioimmunoassay measurement of urinary prostaglandins and thromboxane as a noninvasive indicator of radiation exposure.
摘要
在全身γ射线照射后，未麻醉大鼠的尿液中观察到前列腺素（PGF2α和PGE）和血栓素B2（TxB2）水平与剂量相关的变化。100和900拉德的照射剂量导致这些环氧化酶产物的尿液水平发生显著变化。这些发现表明，放射免疫分析法测量尿中前列腺素和血栓素有可能作为辐射暴露的非侵入性指标。
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