Steel L K, Sweedler I K, Catravas G N
Radiat Res. 1983 Apr;94(1):156-65.
At 1 hr to 14 days after total-body exposure of guinea pigs to 3.0 Gy 60Co, changes were detected in prostaglandin concentrations in bronchial airway tissues. At 3 hr postexposure, tissue levels of PGE were significantly elevated, while at 48 hr transiently elevated levels of PGF2 alpha were observed. By 72 hr, levels returned to control values. Airway synthesis of thromboxane B2 in irradiated animals did not differ from that in controls. Also assessed were the capacities of bronchial airway preparations to respond to H-1 receptor stimulation by the exogenous addition of histamine or transmembrane divalent cation transport stimulation with ionophore. Tissues from irradiated animals demonstrated alterations in the amount and type of prostaglandins generated, varying with time postirradiation.
豚鼠全身暴露于3.0 Gy 60Co后1小时至14天，支气管气道组织中的前列腺素浓度发生了变化。暴露后3小时，PGE的组织水平显著升高，而在48小时观察到PGF2α水平短暂升高。到72小时，水平恢复到对照值。辐照动物气道中血栓素B2的合成与对照动物没有差异。还评估了支气管气道制剂对外源性添加组胺刺激H-1受体或用离子载体刺激跨膜二价阳离子转运的反应能力。辐照动物的组织显示，所产生的前列腺素的数量和类型发生了变化，随辐照后时间而异。
