Porter J P, Said S I, Ganong W F
Neuroendocrinology. 1983 May;36(5):404-8. doi: 10.1159/000123488.
The effect of vasoactive intestinal peptide (VIP) and isoproterenol on renin release in vitro was investigated using an isolated superfused rat glomerular preparation. VIP at a dose of 10(-9)-10(-7) M significantly stimulated renin release in a dose-related manner while 10(-10) M was ineffective. These data are consistent with the hypothesis that VIP is a renin-stimulating factor and can have this effect by acting directly on the renal juxtaglomerular cells.
使用离体灌注大鼠肾小球制备物，研究了血管活性肠肽（VIP）和异丙肾上腺素对体外肾素释放的影响。剂量为10^(-9)-10^(-7)M的VIP以剂量相关方式显著刺激肾素释放，而10^(-10)M无效。这些数据与VIP是一种肾素刺激因子并可通过直接作用于肾球旁细胞发挥此作用的假说一致。
