Baslé M, Kouyoumdjian S, Pouplard A, Rebel A, Filmon R
Pathol Biol (Paris). 1983 Jan;31(1):41-4.
A serological study has been carried out in Paget's bone disease where the etiology still remains uncertain. Previous work on patients with the disease revealed specific osteoclast inclusions that could be linked to the presence of a virus of the paramyxovirus group. Conventional methods for exploring humoral immunity reveal no great differences in the concentration of antibodies against the various viral strains tested on sera from 46 patients with Paget's bone disease and from 46 paired controls. The viral origin of Paget's bone disease is reconsidered in the light of the results obtained. The eventuality of sub-threshold viral infection and the possible action of incomplete or defective virus leading to the chronic nature of the disease are discussed.
在佩吉特骨病病因仍不确定的情况下，开展了一项血清学研究。先前对该病患者的研究发现了特定的破骨细胞内含物，这些内含物可能与副粘病毒科病毒的存在有关。探索体液免疫的传统方法显示，在46例佩吉特骨病患者和46例配对对照者的血清中，针对所检测的各种病毒株的抗体浓度没有显著差异。根据获得的结果重新审视了佩吉特骨病的病毒起源。讨论了亚阈值病毒感染的可能性以及不完整或有缺陷的病毒导致该病慢性化的可能作用。
